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Overall these alterations in metabolism pathways resulted in a substantial reduction in the levels of metabolites such as aspartate, asparagine, glutamine, histidine, N-formimino-glutamate, sarcosine, and ethanolamine phosphate in LC patients ( Figure 4B , Supplementary Figure 3B )
The other patient initially underwent transsphenoidal surgery because of visual disturbance, but endocrinological examinations suggested possible relationships with previous ovarian hyperstimulation
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Two principal branches propagate from there
Here we review the charts of consecutive patients seen in a medically based autism clinic who underwent a systematic workup for mitochondrial disorders per recently published guidelines, which included screening for fatty-acid metabolism disorders
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